Objectives:
1. To determine the percentage loss of weight of the
tablet after being tested with friability tester.
2. To determine tablet’s ability to withstand abrasion.
Introduction:
Friability testing is a laboratory
technique used by the pharmaceutical industry to test the likelihood of a
tablet breaking into smaller pieces, to crumble and break following numerous compression
and therefore it is used to determine the mechanical strength of the tablets.
Besides, this experiment can also be used to determine the ability of tablet to
withstand abrasion in packaging, handling and shipping. Friction and shock are
the forces that most often cause tablets to chip, cap or break.
It involves repeatedly dropping a
sample of tablets over a fixed time, using a rotating wheel with a baffle, and
afterwards checking whether any tablets are broken, and what percentage of the
initial mass of the tablets has been chipped off. The loss due to abrasion is a
measure of the tablet friability. A thick tablet may have less tendency to
fracture whereas thin tablets of large diameter often show extensive capping
and fracturing.
The friability of tablet is caused
by a number of factors including low moisture content, insufficient binding
agent, sharp edges of tablets. Friability test is greatly influenced by moisture
of tablet granules because ideal moisture level can be function as binding agent
of the tablets. The friabilator used in laboratories is the Roche Friabilitor.
Effervescent tablets and chewable tablets normally using special stack packing
because these tablets usually undergo high friability weight loss. Tablets
which prone to fracturization during the test are normally considered unfit for
manufacture and commercial use.
Apparatus and materials:
Ettrocine tablets,
drum of the tablet abrasion, friability tester and weighing boat.
Procedures:
1. 10 tablets were selected and weighed.
2. All tablets were
put into the drum of the tablet abrasion and friability tester. The rate of
rotation was set to 100 rpm, time to 10 minutes and the operation was started.
3. All tablets were removed
at the end of operation and was ensured to be free from dust or powder by using
the brush. The tablets were reweighed. The percentage loss of weight was
determined.
4. Compressed tablet should nor lose more
than 1% of its weight.
Result
:
Name
of tablets: Ettrocine
Initial
weight of 10 tablets : 6.6322 g
Final
weight of 10 tablets : 6.6287 g
Calculations:
Differences
in weight of 10 tablets : 6.6322g –
6.6287g = 0.0035 g
Percentage
loss of weight : 0.0035g /
6.6322g x 100% = 0.0527
= 0.053 %
Discussion：
In friability test the tablets are prone to
abrasion hence enabling us to check for the tablet strength under application
of force in different manner. It can be caused by a number of factors including
poor tablet design (too sharp edges), low moisture content and insufficient
binder. Effervescent tablets and chewable tablets may have different
specifications as far as friability is concerned. In friability test the tablets are prone to
abrasion hence enabling us to check for the tablet strength under application
of force in different manner. Tablets
should be have hard enough so that they do not break up in the bottle however
still friable enough that they disintegrate in the gastrointestinal tract.
Tablets prone to capping during the test are considered unfit for commercial
use. Friability test is influenced by internal factors like the moisture
content of tablet granules and finished tablets. Moisture at low and acceptable
level acts as a binder. In this experiment, the percentage loss of weight of the
tablets is 0.053 % which is not exceeding 1 %, the non-pharmacopeia standard,
therefore these tablets can be indicated to have good friability and have high
ability to resist mechanical shock. It shows that the tablets are capable to
resist mechanical shock and aberration during the test. In this, tablet
friability experiment, 10 Ettrocine tablets were selected and weighed before it
was put into drum of the tablet abrasion and friability tester. The rotation
was done for 10 minutes with speed of rotation 100rpm. In order to determine
the friability of tablets and its ability to withstand abrasion, tablets are
weighed and the weight compared with initial weight. The loss due to abrasion
is measure of tablet friability. The value is expressed in percentage. Minimum
weight loss of the tablet should not be more 1%. There should not be any broken
tablet. The higher the amount of weight loss, the more fragile are the tablets.
Conclusion
:
As
a conclusion, the weight loss of Ettrocine is 0.75% and therefore they have an
ideal friability. The tablets has desired physical strength to overcome the
mechanical shock and abrasion during handling and packaging.
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